The Institute for Earth, Computing, Human and Observing (Institute for ECHO) of Chapman University is an interdisciplinary research unit reporting to the Provost that covers several areas as its name implies. Amongst them is the Earth and its many systems including humans viewed as living systems in specific activities. Focused scientific areas include natural hazards such as wildfires, severe weather, floods, air pollution, and earthquakes; the changing Earth’s climate and impacts on agriculture, economic factors, the atmosphere, and the oceans. Areas of excellence also include central aspects of modern physics involving humans, such as quantum mechanics and the role of the mind, brain science, observations of the universe, in which the planet Earth, the Sun, humans, and all life are found and the structure of space-time. ECHO scientists use state-of-the-art regional climate modeling, Earth observations, advanced data analysis, machine and deep learning, and spatial analysis to study some of these different environments. Aspects of neuroscience as well as cognition and the role of the mind in structuring reality are interdisciplinary and transdisciplinary topics of interest to ECHO. Specific to quantum mechanics and cognition, the interplay of the mind of the participating observer revealing quantum principles and how the observer is tied to the observed system, form foundational philosophical inquires. Echoes of existence cover so many fundamental aspects of reality from quantum wave functions to echoes of the Earth itself as a living system of systems. The multitude areas of research among ECHO faculty, affiliated faculty, postdoctoral fellows, international collaborators and students reflect both the interdisciplinary nature of ECHO and transdisciplinary links over many scales and areas that are natural to an Institute of the caliber of ECHO.